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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal INRAE Université de Liège Université de Lille Université Picardie Jules Verne Associated institutions

UMR Transfrontalière BioEcoAgro (

Green biological and separation processes intersection

This transversal axis aims to federate the members of various teams of the cross-border UMR, who within the framework of their research activities develop concepts of process engineering applied to biological systems. This is about doing systemic research in biotechnological and food bioprocessing.


Loubna Firdaous and Krasimir Dimitrov, ICV, intersection leaders

Loubna Firdaous and Krasimir Dimitrov, ICV, intersection leaders

Thus, the transversal axis “Green biological and separative processes” aims to ensure the scientific animation of the UMR in process engineering and to affirm as a priority fundamental research in bioprocesses and separative processes, in intensification of bioprocesses through coupling using LCA and energy consumption to assess the environmental impact. It is about designing new eco processes for the production of natural molecules respectful of the environment and health in the context of the factory of the future. 

Teams 4, 5, 6 and 7 have long been involved in a logic of development and optimization of processes allowing the bioproduction of molecules by enzymatic catalysis, by fermentation, from plants and the extraction and purification of these active ingredients. Given the diversification of resources and molecules produced, it is necessary to address the problems by a systemic analysis of the processes in this transversality which ultimately is the framework of the structure that is the INRAE ​​BioEcoAgro UMRT. 

The integration of these process concepts is taken into account very early on in all of the unit's teams and its great originality lies in the complete and unique value chain at its disposal, allowing it:

  1. To design and develop bioproduction processes on a millimeter and milliliter scale and to study the scaling up and its modeling through pilot steps to 100 liters to lead to demonstrators of 2000 liters.
  2. To set up improvement and innovation strategies in the separation processes allowing the obtaining of fraction or target molecules from complex production medium.
  3. To design new eco-processes and favor the intensification of processes by coupling the bioreaction to separation or integration.
  4. To control the environmental and energy impact as well as the cost and productivity throughout the chain.
  5. To manufacture batches of biomolecules of sufficient size to validate their use on a large scale while preserving their biological activity and maintaining their status as natural molecules.
  6. To study the formulation and stability of the product upstream of its applicability.

This transversal approach combining the concepts of process engineering and biological engineering has made it possible to be structuring and driving force for the associated international laboratory “LIAAN” created with INAF at Laval University. The teaching researchers of this transversality are members and active of the European Society of Biochemical Engineering Sciences, of the FF Biotech (member of the board), of the SFGP by co-animating two WGs: Bioprocesses and separation processes, of ADEBIOTECH (1 seat at the CA), CFM, IAR cluster by co-hosting the “enzymatic catalysis and associated processes” WG and SFR Condorcet.

Bioreactor 500L

Bioreactor 500L